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Introduction and Principle of the
Test In about 80 % of patients with Myasthenia gravis alterations of the thymus can be detected. Approximately 10 % of these patients develop thymus neoplasia as thymic epithelial tumor (TET) or thymic carcinoma. An early diagnosis of the thymoma and subsequent thymectomy is crucial for the prognosis of these patients. Most of these patients develop, in addition to the acetylcholine receptor antibodies detected in myasthenia gravis (ACHRAB-Assay), other autoantibodies against striated muscle, including antibodies against titin.
Assay Type : Quantitative
Pack Size : 96 wells
Storage : 2-8°C
Clinical Fields : Neurology, Immunology, autoimmune diseases
Characteristics : Significantly more specific than the determination of antibodies against striated muscle by immunofluorescence
- recombinant MGT30 peptide for antigen
-differentiation from thymic hyperplasia
- simple and quick handling, incubation time 2 hours.
Mon - Sat: 10AM - 06PM
Storage and Stability
The kit is shipped at ambient temperature and is subsequently stable until the stated expiry date when stored between 2 - 8 °C. Once opened, the kit is stable until the expiry date. The shelf life of the ready-to-use reagents is indicated on the respective bottle label. The shelf life and storage conditions of the prepared reagents is stated under 6.1. Bring all reagents to room temperature before use and refrigerate immediately after use.
Sample Collection and Storage
Serum and Plasma
Only serum or plasma should be used for the test. Follow the instructions provided by the manufacturer of the blood collection system. The usual precautions for blood collection must be observed. Freshly collected samples should be used. If necessary, the serum or plasma samples can be stored at -20 °C. Avoid repeated freezing and thawing. Hemolytic, lipemic and iteric samples should not be used.
Reproducibility
Reproducibility was determined by calculating the intra- and inter-assay coefficients of variation.
Values are given as ODsample/ODcalibrator.
Assay Characteristics
In the following the results of determining each 86 serum and EDTA plasma samples of normal healthy blood donors are shown. The following graphs show the distribution of the normal values.
The reference range is given as factor F < 1.0
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