DLD Histamine ELISA

Histamine (β-imidazole-ethylamine) a biogenic amine, is a product of the histidine metabolism. It is produced by decarboxylation of histidine. Histamine is widely distributed in mammalian tissues. It is bound to heparin (as inactive form) and stored in the granules of basophilic leukocytes and mast cells and is actively released as required. These cells, if sensitized by IgE antibodies attached to their membranes, degranulate when exposed to the appropriate antigen.

It is involved in the defense against foreign substances and its pathological reactions lead to symptoms such as allergies and asthma. Histamine plays a major rule in the initial phase of an anaphylactic reaction. The quantification of histamine in plasma after allergen administration is of clinical interest.

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